Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection

Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection Full article

Journal

ChemMedChem
ISSN: 1860-7179 , E-ISSN: 1860-7187

Output data

Year: 2019, Volume: 14, Number: 4, Pages: 454-461 Pages count : 8 DOI: 10.1002/cmdc.201800718

Authors

Asquith Christopher R.M. ^1,2,7 , Laitinen Tuomo ³ , Konstantinova Lidia S. ^5,4 , Tizzard Graham J. ⁶ , Poso Antii ³ , Rakitin Oleg A. ^5,4 , Hofmann-Lehmann Regina ² , Hilton Stephen T. ¹

Affiliations

1	School of Pharmacy, Faculty of Life Sciences, University College London, London, WC1N 1AX UK
2	Clinical Laboratory & Center for Clinical Studies, Vetsuisse Faculty University of Zurich 8057 Zurich Switzerland
3	School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211 Finland
4	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russian Federation
5	Nanotechnology Education and Research Center, South Ural State University, Lenina Ave. 76, Chelyabinsk, Russian Federation
6	UK National Crystallography Service, School of Chemistry, University of Southampton, Highfield Campus, Southampton, SO17 1BJ UK
7	Current address: Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Genetic Medicine Building, Chapel Hill, NC, 27599 USA

A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.

Asquith C.R.M. , Laitinen T. , Konstantinova L.S. , Tizzard G.J. , Poso A. , Rakitin O.A. , Hofmann-Lehmann R. , Hilton S.T.
Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
ChemMedChem. 2019. V.14. N4. P.454-461. DOI: 10.1002/cmdc.201800718 WOS Scopus OpenAlex

Web of science:	WOS:000458933200003
Scopus:	2-s2.0-85060620375
OpenAlex:	W2907166246

DB	Citing
OpenAlex	16
Scopus	16
Web of science	13