Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2019, Volume: 68, Number: 1, Pages: 158-162 Pages count : 5 DOI: 10.1007/s11172-019-2431-5

Authors

Pukhov S.A. ¹ , Anikina L.A. ¹ , Larin A.A. ² , Fershtat L.L. ² , Kulikov A.S. ² , Makhova N.N. ²

Affiliations

1	Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol- 3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.

Pukhov S.A. , Anikina L.A. , Larin A.A. , Fershtat L.L. , Kulikov A.S. , Makhova N.N.
Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells
Russian Chemical Bulletin. 2019. V.68. N1. P.158-162. DOI: 10.1007/s11172-019-2431-5 WOS Scopus OpenAlex

Web of science:	WOS:000464854400024
Scopus:	2-s2.0-85064428239
OpenAlex:	W2939571051

DB	Citing
OpenAlex	11
Scopus	9
Web of science	10