Glycosylation in flow: effect of the flow rate and type of the mixer

Glycosylation in flow: effect of the flow rate and type of the mixer Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2019, Volume: 68, Number: 11, Pages: 2126-2129 Pages count : 4 DOI: 10.1007/s11172-019-2677-y

Authors

Myachin I.V. ^1,2 , Orlova A.V. ² , Kononov L.O. ^2,3

Affiliations

1	D. I. Mendeleev University of Chemical and Technology of Russia, 9 Miusskaya pl., 125047, Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
3	Moscow Physical Technical Institute (National Research University), 9 Institutsky per., 141701 Dolgoprudnyi, Moscow Region, Russian Federation

The influence of the flow rate and the mode of mixing of reagent solutions on the result of glycosylation of isopropyl alcohol with glycooxazoline in 1,2-dichloroethane in the presence of (±)-camphor-10-sulfonic acid was studied. No reaction products were observed at low flow rates (⩽0.043 mL h−1) when using two Comet X-01 micromixers. Under these conditions, the disaggregation of supramers of the reagents is apparently inefficient for the reaction between them to occur. However, when one of the Comet X-01 micromixers was replaced with a T-shaped adapter (at the same flow rate), the expected reaction products, glycoside and glycal, appeared in the reaction mixture. This apparently suggests a higher disaggregation of the supramers reagents under these conditions, which allows the chemical reaction between them to occur.

Myachin I.V. , Orlova A.V. , Kononov L.O.
Glycosylation in flow: effect of the flow rate and type of the mixer
Russian Chemical Bulletin. 2019. V.68. N11. P.2126-2129. DOI: 10.1007/s11172-019-2677-y WOS Scopus OpenAlex

Web of science:	WOS:000510659800025
Scopus:	2-s2.0-85076440692
OpenAlex:	W2995939227

DB	Citing
OpenAlex	5
Scopus	7
Web of science	7