Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues

Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues Full article

Journal

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Output data

Year: 2019, Volume: 21, Number: 23, Pages: 9608-9612 Pages count : 5 DOI: 10.1021/acs.orglett.9b03780

Authors

Yadykov Anton V. ¹ , Scherbakov Alexander M. ² , Trofimova Victoria V. ³ , Lvov Andrey G. ¹ , Markosyan Ashot I. ⁴ , Zavarzin Igor V. ¹ , Shirinian Valerii Z. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, RAS, 47, Leninsky prosp., 119991 Moscow, Russian Federation
2	N. N. Blokhin National Medical Research Center of Oncology, Kashirskoye sh. 24, 115522 Moscow, Russian Federation
3	D.I. Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russian Federation
4	Scientific Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan 0014, Republic of Armenia

The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results in a photorearrangement giving products with relatively low antiproliferative activity. The observed ability of this series CA-4 to the photodegradation can be used for the design of a new class of drug candidates with high selectivity to cancer cells.

Yadykov A.V. , Scherbakov A.M. , Trofimova V.V. , Lvov A.G. , Markosyan A.I. , Zavarzin I.V. , Shirinian V.Z.
Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues
Organic Letters. 2019. V.21. N23. P.9608-9612. DOI: 10.1021/acs.orglett.9b03780 WOS Scopus OpenAlex

Web of science:	WOS:000502163300069
Scopus:	2-s2.0-85075160092
OpenAlex:	W2988819026

DB	Citing
OpenAlex	27
Scopus	26
Web of science	26