Facile Synthesis of Carboxamide-Substituted 1,3,4-Thiadiazines and 5,6-Dihydro-4H-1,3,4-Thiadiazin-5-Ols

Facile Synthesis of Carboxamide-Substituted 1,3,4-Thiadiazines and 5,6-Dihydro-4H-1,3,4-Thiadiazin-5-Ols Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2019, Volume: 55, Number: 7, Pages: 665-671 Pages count : 7 DOI: 10.1007/s10593-019-02514-5

Authors

Komendantova Anna S. ¹ , Ivanova Ksenya A. ¹ , Lyssenko Konstantin V. ^2,3 , Volkova Yulia A. ¹ , Zavarzin Igor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., GSP-1, Moscow 119991, Russia
3	Plekhanov Russian University of Economics, 36 Stremyannyy Pereulok, Moscow 117997, Russia

Novel 2-carboxamide-substituted 1,3,4-thiadiazines and 5,6-dihydro-4H-1,3,4-thiadiazin-5-ols were synthesized by the reaction of oxamic acid thiohydrazides with phenacyl bromides. This reaction was performed using an equimolar mixture of thiohydrazide and α-bromoacetophenones in methanol under basic conditions. The ratio of products obtained in the cyclocondensation was found to be strongly dependent on the substitution pattern and reaction conditions.

Komendantova A.S. , Ivanova K.A. , Lyssenko K.V. , Volkova Y.A. , Zavarzin I.V.
Facile Synthesis of Carboxamide-Substituted 1,3,4-Thiadiazines and 5,6-Dihydro-4H-1,3,4-Thiadiazin-5-Ols
Chemistry of Heterocyclic Compounds. 2019. V.55. N7. P.665-671. DOI: 10.1007/s10593-019-02514-5 WOS Scopus OpenAlex

≡ Web of science:	WOS:000483688800015
≡ Scopus:	2-s2.0-85070887388
≡ OpenAlex:	W2964720836