Stereoselective multicomponent synthesis of (2RS,6SR)-2,6-diaryl-3,3,5,5-tetracyanopiperidines

Stereoselective multicomponent synthesis of (2RS,6SR)-2,6-diaryl-3,3,5,5-tetracyanopiperidines Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2018, Volume: 67, Number: 8, Pages: 1534-1537 Pages count : 4 DOI: 10.1007/s11172-018-2252-y

Authors

Vereshchagin A.N. ¹ , Karpenko K.A. ¹ , Elinson M.N. ¹ , Gorbunov S.V. ¹ , Anisina Yu.E. ¹ , Egorov M.P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Multicomponent reaction between alkylidenemalononitriles, formaldehyde, and ammonium acetate upon reflux in alcohols gives stereoselectively 2,6-diaryl-3,3,5,5-tetracyanopiperidines in 65—92% yields. In this process, ammonium acetate acts as both a catalyst and a source of nitrogen for the piperidine ring.

Vereshchagin A.N. , Karpenko K.A. , Elinson M.N. , Gorbunov S.V. , Anisina Y.E. , Egorov M.P.
Stereoselective multicomponent synthesis of (2RS,6SR)-2,6-diaryl-3,3,5,5-tetracyanopiperidines
Russian Chemical Bulletin. 2018. V.67. N8. P.1534-1537. DOI: 10.1007/s11172-018-2252-y WOS Scopus OpenAlex

Web of science:	WOS:000448221900033
Scopus:	2-s2.0-85055323706
OpenAlex:	W2898397207

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OpenAlex	7
Scopus	7
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