Studies on quinazolines 7*. Alkylation of 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines with methyl iodide

Studies on quinazolines 7*. Alkylation of 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines with methyl iodide Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2018, Volume: 54, Number: 9, Pages: 887-891 Pages count : 5 DOI: 10.1007/s10593-018-2363-2

Authors

Gromachevskaya Elena V. ¹ , Kaigorodova Elena А. ² , Konyushkin Leonid D. ³ , Krapivin Gennady D. ¹

Affiliations

1	Kuban State Technological University, 2 Moskovskaya St, Krasnodar, 350072, Russia
2	Kuban State Agrarian University, 13 Kalinina St, Krasnodar, 350044, Russia
3	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

The reaction of 2-aryl-4,4-diphenyl-3,4-dihydroquinazoline with methyl iodide in acetone in the presence of potassium hydroxide at 40°C leads to the formation of the corresponding 1-methyl-4,4-diphenyl-1,4-dihydroquinazolines and 1,3-dimethyl-4,4-diphenyl-1,4-dihydroquinazolin-3-ium iodides. The structure of 2-(7-methoxy-1,3-benzodioxol-5-yl)-1-methyl-4,4-diphenyl-1,4-dihydroquinazoline was established by heteronuclear correlation NMR spectroscopy.

Gromachevskaya E.V. , Kaigorodova E.А. , Konyushkin L.D. , Krapivin G.D.
Studies on quinazolines 7*. Alkylation of 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines with methyl iodide
Chemistry of Heterocyclic Compounds. 2018. V.54. N9. P.887-891. DOI: 10.1007/s10593-018-2363-2 WOS Scopus OpenAlex

≡ Web of science:	WOS:000449947000009
≡ Scopus:	2-s2.0-85055880306
≡ OpenAlex:	W2899505543