Efficient and facile ‘on-solvent’ multicomponent synthesis of medicinally privileged pyrano[3,2-c]pyridine scaffold

Efficient and facile ‘on-solvent’ multicomponent synthesis of medicinally privileged pyrano[3,2-c]pyridine scaffold Full article

Journal

Research on Chemical Intermediates
ISSN: 0922-6168 , E-ISSN: 1568-5675

Output data

Year: 2018, Volume: 44, Number: 5, Pages: 3199-3209 Pages count : 11 DOI: 10.1007/s11164-018-3301-8

Authors

Elinson Michail N. ¹ , Ryzhkov Fedor V. ¹ , Vereshchagin Anatoly N. ¹ , Goloveshkin Alexander S. ² , Bushmarinov Ivan S. ² , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia
2	A. N. Nesmeyanov Organoelement Compounds Institute, Moscow, Russia

The new type of ‘on-solvent’ multicomponent reaction was found: transformation of benzaldehydes, malononitrile and 4–hydroxy-6-methylpyridin-2(1H)-one in the presence of sodium acetate as catalyst in a small amount of ethanol results in formation of substituted 2-amino-7-methyl-5-oxo-4-phenyl-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles in excellent 92–99% yields. This novel ‘one-pot’ process opens an efficient and convenient way to functionalize pyrano[3,2-c]pyridine systems, which are promising compounds for different biomedical applications.

Elinson M.N. , Ryzhkov F.V. , Vereshchagin A.N. , Goloveshkin A.S. , Bushmarinov I.S. , Egorov M.P.
Efficient and facile ‘on-solvent’ multicomponent synthesis of medicinally privileged pyrano[3,2-c]pyridine scaffold
Research on Chemical Intermediates. 2018. V.44. N5. P.3199-3209. DOI: 10.1007/s11164-018-3301-8 WOS Scopus OpenAlex

Web of science:	WOS:000429485300016
Scopus:	2-s2.0-85041128049
OpenAlex:	W2791307228

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