Novel Acinetobacter baumannii Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase

Novel Acinetobacter baumannii Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase Full article

Journal

Viruses
ISSN: 1999-4915

Output data

Year: 2021, Volume: 13, Number: 9, Article number : 1688, Pages count : DOI: 10.3390/v13091688

Authors

Timoshina Olga Yu ^1,2 , Shneider Mikhail M ² , Evseev Peter V ² , Shchurova Anastasia S ³ , Shelenkov Andrey A ¹ , Mikhaylova Yulia V ¹ , Sokolova Olga S ^4,5 , Kasimova Anastasia A ⁶ , Arbatsky Nikolay P ⁶ , Dmitrenok Andrey S ⁶ , Knirel Yuriy A ⁶ , Miroshnikov Konstantin A ² , Popova Anastasia V ⁷

Affiliations

1	Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia
2	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
3	Moscow Institute of Physics and Technology, National Research University, Institutskiy per. 9, Dolgoprudny, 141700 Moscow, Russia
4	Biology Department, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia
5	Biology Department, Shenzhen MSU-BIT University, 1 International University Park Road, Longgang District, Shenzhen 518172, China
6	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia
7	State Research Center for Applied Microbiology and Biotechnology, 24 “Quarter A” Territory, Obolensk, City District Serpukhov, 142279 Moscow, Russia

Acinetobacter baumannii appears to be one of the most crucial nosocomial pathogens. A possible component of antimicrobial therapy for infections caused by extremely drug-resistant A. baumannii strains may be specific lytic bacteriophages or phage-derived enzymes. In the present study, we observe the biological features, genomic organization, and phage–host interaction strategy of novel virulent bacteriophage Aristophanes isolated on A. baumannii strain having K26 capsular polysaccharide structure. According to phylogenetic analysis phage Aristophanes can be classified as a representative of a new distinct genus of the subfamily Beijerinckvirinae of the family Autographiviridae. This is the first reported A. baumannii phage carrying tailspike deacetylase, which caused O-acetylation of one of the K26 sugar residues.

Timoshina O.Y. , Shneider M.M. , Evseev P.V. , Shchurova A.S. , Shelenkov A.A. , Mikhaylova Y.V. , Sokolova O.S. , Kasimova A.A. , Arbatsky N.P. , Dmitrenok A.S. , Knirel Y.A. , Miroshnikov K.A. , Popova A.V.
Novel Acinetobacter baumannii Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase
Viruses. 2021. V.13. N9. 1688 . DOI: 10.3390/v13091688 WOS Scopus OpenAlex

Web of science:	WOS:000702096800001
Scopus:	2-s2.0-85113943618
OpenAlex:	W3194436015

DB	Citing
OpenAlex	14
Scopus	12
Web of science	10