Novel L-threonine-based ionic liquid supported organocatalyst for asymmetric syn-aldol reaction: activity and recyclability design

Novel L-threonine-based ionic liquid supported organocatalyst for asymmetric syn-aldol reaction: activity and recyclability design Full article

Journal

Arkivoc
ISSN: 1551-7012 , E-ISSN: 1551-7004

Output data

Year: 2017, Number: 3, Pages: 241-249 Pages count : 9 DOI: 10.24820/ark.5550190.p010.149

Authors

Gerasimchuk Vasiliy V. ¹ , Romanov Roman R. ² , Woo Gladys H.-T. ³ , Dmitriev Igor A. ¹ , Kucherenko Alexander S. ¹ , Zlotin Sergei G. ¹

Affiliations

1	Zelinsky Institute of Organic Chemistry, Leninsky prospect 47, 119 991, Moscow, Russia
2	Moscow Chemical Lyceum, Tamogeny proezd 4, 111 033, Moscow, Russia
3	National Junior College, 37 Hillcrest Road, 288 913, Singapore

A novel recyclable threonine-derived ionic-liquid-supported organocatalyst of asymmetric cross-aldol reactions has been developed. In its presence, aromatic aldehydes react with hydroxyacetone, methoxyacetone and 2-butanone to afford the corresponding syn-aldol products in moderate to high yields with excellent diastereo- (syn/anti up to 96:4) and enantio-selectivity (up to 95 % ee), which was retained over five recycling experiments.

Gerasimchuk V.V. , Romanov R.R. , Woo G.H.-T. , Dmitriev I.A. , Kucherenko A.S. , Zlotin S.G.
Novel L-threonine-based ionic liquid supported organocatalyst for asymmetric syn-aldol reaction: activity and recyclability design
Arkivoc. 2017. N3. P.241-249. DOI: 10.24820/ark.5550190.p010.149 WOS Scopus OpenAlex

Web of science:	WOS:000408556800021
Scopus:	2-s2.0-85026795131
OpenAlex:	W2774764052

DB	Citing
OpenAlex	2
Scopus	5
Web of science	3