Branching tryptamines as a tool to tune their antiproliferative activity

Branching tryptamines as a tool to tune their antiproliferative activity Full article

Journal

European Journal of Medicinal Chemistry
ISSN: 1768-3254 , E-ISSN: 0223-5234

Output data

Year: 2018, Volume: 144, Pages: 211-217 Pages count : 7 DOI: 10.1016/j.ejmech.2017.12.028

Authors

Salikov Rinat F. ¹ , Trainov Konstantin P. ¹ , Belousova Irina K. ² , Belyy Aleksandr Yu. ¹ , Fatkullina Ulyana Sh. ³ , Mulyukova Regina V. ³ , Zainullina Liana F. ^4,3 , Vakhitova Yulia V. ^4,3 , Tomilov Yury V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation
2	Moscow Chemical Lyceum, 4 Tamozhennyj Proezd, 111033 Moscow, Russian Federation
3	Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, pr. Oktyabrya 71, 450054 Ufa, Russian Federation
4	Department of Pharmacogenetics, Zakusov Institute of Pharmacology, 8 Baltiyskaya ul., 125315 Moscow, Russian Federation

The influence of a series of tryptamine derivatives on the viability of normal (HEK293) and tumor (HepG2, Jurkat and SH-SY5Y) cells has been evaluated. All tryptamines tested were three different substitution types: C- and N-branching, and indole benzylation. All the derivations enhance the activity of compounds separately, although the effects of different substitutions were not additive. Thus, combinations of C- and N-branchings as well as C-branching and indole benzylation gave little or no increase in activity.

Salikov R.F. , Trainov K.P. , Belousova I.K. , Belyy A.Y. , Fatkullina U.S. , Mulyukova R.V. , Zainullina L.F. , Vakhitova Y.V. , Tomilov Y.V.
Branching tryptamines as a tool to tune their antiproliferative activity
European Journal of Medicinal Chemistry. 2018. V.144. P.211-217. DOI: 10.1016/j.ejmech.2017.12.028 WOS Scopus OpenAlex

≡ Web of science:	WOS:000425198100016
≡ Scopus:	2-s2.0-85038812234
≡ OpenAlex:	W2774714762