The Antimicrobial and Antibiofilm Potential of New Water-Soluble Tris-Quaternary Ammonium Compounds

The Antimicrobial and Antibiofilm Potential of New Water-Soluble Tris-Quaternary Ammonium Compounds Full article

Journal

International Journal of Molecular Sciences
ISSN: 1661-6596 , E-ISSN: 1422-0067

Output data

Year: 2023, Volume: 24, Number: 13, Article number : 10512, Pages count : DOI: 10.3390/ijms241310512

Authors

Frolov Nikita A. ¹ , Seferyan Mary A. ¹ , Valeev Anvar B. ^2,1 , Saverina Evgeniya A. ^3,1 , Detusheva Elena V. ^1,4 , Vereshchagin Anatoly N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia
2	Higher Chemical College of the Russian Academy of Sciences, D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, 125047 Moscow, Russia
3	Laboratory of Biologically Active Compounds and Biocomposites, Tula State University, Lenin Prospect. 92, 300012 Tula, Russia
4	State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia

The invention and innovation of highly effective antimicrobials are always crucial tasks for medical and organic chemistry, especially at the current time, when there is a serious threat of shortages of effective antimicrobials following the pandemic. In the study presented in this article, we established a new approach to synthesizing three novel series of bioactive water-soluble tris-quaternary ammonium compounds using an optimized one-pot method, and we assessed their antimicrobial and antibiofilm potential. Five pathogenic microorganisms of the ESKAPE group, including highly resistant clinical isolates, were used as the test samples. Moreover, we highlighted the dependence of antibacterial activity from the hydrophilic–hydrophobic balance of the QACs and noted the significant performance of the desired products on biofilms with MBEC as low as 16 mg/L against bacteria and 8 mg/L against fungi. Particularly notable was the high activity against Pseudomonas aeruginosa and Acinetobacter baumannii, which are among the most resilient bacteria known. The presented work will provide useful insights for future research on the topic.

Frolov N.A. , Seferyan M.A. , Valeev A.B. , Saverina E.A. , Detusheva E.V. , Vereshchagin A.N.
The Antimicrobial and Antibiofilm Potential of New Water-Soluble Tris-Quaternary Ammonium Compounds
International Journal of Molecular Sciences. 2023. V.24. N13. 10512 . DOI: 10.3390/ijms241310512 WOS Scopus OpenAlex

Web of science:	WOS:001028564800001
Scopus:	2-s2.0-85164843085
OpenAlex:	W4381804313

DB	Citing
OpenAlex	6
Scopus	5
Web of science	6