Selective multicomponent ‘one-pot’ approach to the new 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)chromeno[2,3-b]pyridine scaffold in pyridine–ethanol catalyst/solvent system

Selective multicomponent ‘one-pot’ approach to the new 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)chromeno[2,3-b]pyridine scaffold in pyridine–ethanol catalyst/solvent system Full article

Journal

Monatshefte Fur Chemie
ISSN: 1434-4475 , E-ISSN: 0026-9247

Output data

Year: 2019, Volume: 150, Number: 6, Pages: 1073-1078 Pages count : 6 DOI: 10.1007/s00706-019-02388-5

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Anisina Yuliya E. ¹ , Krymov Stepan K. ² , Fakhrutdinov Artem N. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
2	D. I. Mendeleev University of Chemical Technology, Miusskaya sq. 9, Moscow 125047, Russian Federation

The new multicomponent reaction was found: the pyridine-catalyzed transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and 4-hydroxy-6-methyl-2H-pyran-2-one in small amount of pyridine–ethanol solvent system results in selective and efficient formation of the earlier unknown substituted 2,4-diamino-5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 45–85% yields. This new multicomponent process provides facile and efficient way to the new type of functionalized 5-C-substituted chromeno[2,3-b]pyridine scaffold, containing 4-hydroxy-6-methyl-2H-pyran-2-one fragment, which are promising compounds for different biomedical applications.

Elinson M.N. , Vereshchagin A.N. , Anisina Y.E. , Krymov S.K. , Fakhrutdinov A.N. , Egorov M.P.
Selective multicomponent ‘one-pot’ approach to the new 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)chromeno[2,3-b]pyridine scaffold in pyridine–ethanol catalyst/solvent system
Monatshefte Fur Chemie. 2019. V.150. N6. P.1073-1078. DOI: 10.1007/s00706-019-02388-5 WOS Scopus OpenAlex

Web of science:	WOS:000469766500011
Scopus:	2-s2.0-85065719830
OpenAlex:	W2945529171

DB	Citing
OpenAlex	15
Scopus	14