Synthesis of 4″O,5O-bis(2-amino-2-thioxoacetyl)ivermectin derivatives

Synthesis of 4″O,5O-bis(2-amino-2-thioxoacetyl)ivermectin derivatives Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2019, Volume: 68, Number: 5, Pages: 1109-1115 Pages count : 7 DOI: 10.1007/s11172-019-2527-y

Authors

Shchetinina M.A. ¹ , Chernoburova E.I. ¹ , Kolotyrkina N.G. ¹ , Kovalev G.I. ² , Tsepilova I.I. ³ , Krivonos K.S. ³ , Kolobov A.V. ⁴ , Dzhafarov M.Kh. ³ , Tikhonova T.A. ¹ , Volkova Yu.A. ¹ , Vasilevich F.I. ³ , Zavarzin I.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	Scientifi c-Research Institute of Pharmacology named after V. V. Zakusov, 8 ul. Baltiiskaya, 125315 Moscow, Russian Federation
3	K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 23 ul. Аkad. Skryabina, 109472 Moscow, Russian Federation
4	Yaroslavl State Technical University, 88 Moskovskii prosp., 150023 Yaroslavl, Russian Federation

Reaction of 4″O,5O-bis(chloroacetyl)ivermectin with amines in the presence of sulfur provided the corresponding bis(2-amino-2-thioxoacetyl) derivatives that are potential antiparasitics.

Shchetinina M.A. , Chernoburova E.I. , Kolotyrkina N.G. , Kovalev G.I. , Tsepilova I.I. , Krivonos K.S. , Kolobov A.V. , Dzhafarov M.K. , Tikhonova T.A. , Volkova Y.A. , Vasilevich F.I. , Zavarzin I.V.
Synthesis of 4″O,5O-bis(2-amino-2-thioxoacetyl)ivermectin derivatives
Russian Chemical Bulletin. 2019. V.68. N5. P.1109-1115. DOI: 10.1007/s11172-019-2527-y WOS Scopus OpenAlex

≡ Web of science:	WOS:000471201700025
≡ Scopus:	2-s2.0-85067205598
≡ OpenAlex:	W2950807285