Acyl derivatives of ivermectin 5-oxime with antifungal activity

Acyl derivatives of ivermectin 5-oxime with antifungal activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2019, Volume: 68, Number: 2, Pages: 438-444 Pages count : 7 DOI: 10.1007/s11172-019-2405-7

Authors

Chernoburova E.I. ¹ , Shchetinina M.A. ¹ , Dzhafarov M.Kh. ¹ , Krylov V.B. ¹ , Zavarzin I.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation

Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4″-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.

Chernoburova E.I. , Shchetinina M.A. , Dzhafarov M.K. , Krylov V.B. , Zavarzin I.V.
Acyl derivatives of ivermectin 5-oxime with antifungal activity
Russian Chemical Bulletin. 2019. V.68. N2. P.438-444. DOI: 10.1007/s11172-019-2405-7 WOS Scopus OpenAlex

≡ Web of science:	WOS:000464855500027
≡ Scopus:	2-s2.0-85064570168
≡ OpenAlex:	W2936607110