Sciact
  • EN
  • RU

Carbohydrate Specificity of Antibodies Against Yeast Preparations of Saccharomyces cerevisiae and Candida krusei Научная публикация

Журнал Applied Biochemistry and Microbiology
ISSN: 1608-3024 , E-ISSN: 0003-6838
Вых. Данные Год: 2018, Том: 54, Номер: 6, Страницы: 665-669 Страниц : 5 DOI: 10.1134/s0003683818060108
Авторы Krylov V.B. 1 , Petruk M.I. 1 , Karelin A.A. 1 , Yashunuskii D.V. 1 , Tsvetkov Yu.E. 1 , Glushko N.I. 2 , Khaldeeva E.V. 2 , Mokeeva V.L. 3 , Bilanenko E.N. 3 , Lebedin Y.S. 4 , Eremin S.A. 3 , Nifantiev N.E. 1
Организации
1 Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2 Kazan Research Institute of Epidemiology and Microbiology, Kazan, Russia
3 Lomonosov Moscow State University, Moscow, Russia
4 XEMA Company Limited, Moscow, Russia

Реферат: Laboratory animals (the California rabbit) were immunized with natural preparations of Saccharomyces cerevisiae and Candida krusei yeasts. The resulting sera have been analyzed with ligand libraries constructed from synthetic oligosaccharides related to the main carbohydrate components of the fungal cell wall. It is shown that the antibodies in the studied sera predominantly recognize mannan fragments, with the carbohydrate specificity profile being different for S. cerevisiae and C. krusei. Sera against S. cerevisiae contained antibodies that recognize β-glucan, and the minimal recognizable epitope is linear trisaccharide. These results are necessary for the creation of needed immunoenzyme diagnostics for the detection and species characterization of fungi.
Библиографическая ссылка: Krylov V.B. , Petruk M.I. , Karelin A.A. , Yashunuskii D.V. , Tsvetkov Y.E. , Glushko N.I. , Khaldeeva E.V. , Mokeeva V.L. , Bilanenko E.N. , Lebedin Y.S. , Eremin S.A. , Nifantiev N.E.
Carbohydrate Specificity of Antibodies Against Yeast Preparations of Saccharomyces cerevisiae and Candida krusei
Applied Biochemistry and Microbiology. 2018. V.54. N6. P.665-669. DOI: 10.1134/s0003683818060108 WOS Scopus OpenAlex
Идентификаторы БД:
≡ Web of science: WOS:000453844800014
≡ Scopus: 2-s2.0-85058849390
≡ OpenAlex: W2903666783
Альметрики: