Assessing Ge-132 as an antioxidant in organic and water-containing media

Assessing Ge-132 as an antioxidant in organic and water-containing media Full article

Journal

Journal of Organometallic Chemistry
ISSN: 1872-8561 , E-ISSN: 0022-328X

Output data

Year: 2018, Volume: 858, Pages: 8-13 Pages count : 6 DOI: 10.1016/j.jorganchem.2018.01.004

Authors

Vishtorskaya Antonina A. ^1,2 , Saverina Evgeniya A. ^1,2,3 , Pechennikov Valery M. ² , Krylova Irina V. ¹ , Lalov Andrey V. ¹ , Syroeshkin Mikhail A. ¹ , Egorov Mikhail P. ¹ , Jouikov Viatcheslav V. ³

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry RAS, Moscow, Russia
2	I.M. Sechenov First Moscow State Medical University, Russia
3	UMR CNRS 6226 ISCR, University of Rennes 1, Rennes, France

The antioxidant activity of Ge-132 (2-carboxyethylgermanium sesquioxide, [(O0.5)3GeCH2CH2COOH]n), a widely used organic germanium dietary supplement, was assessed by cyclic voltammetry and through its interaction with a stable radical 2,2,-diphenyl-1-picrylhydrazyl (DPPH) monitored by UV-Vis and EPR spectroscopy in water, CH3CN, DMF, MeOH, and their mixtures with water. The results obtained by these methods are coherent in that Ge-132 can manifest its antioxidant activity only in the absence of water because the latter hydrolyses its Ge-O-Ge fragment responsible for quenching free radicals. Thus, contrary to a common use of Ge-132 as a water-soluble agent, it can act as an antioxidant solely in a lipid environment, which is important for understanding the mechanism of its biological activity.

Vishtorskaya A.A. , Saverina E.A. , Pechennikov V.M. , Krylova I.V. , Lalov A.V. , Syroeshkin M.A. , Egorov M.P. , Jouikov V.V.
Assessing Ge-132 as an antioxidant in organic and water-containing media
Journal of Organometallic Chemistry. 2018. V.858. P.8-13. DOI: 10.1016/j.jorganchem.2018.01.004 WOS Scopus OpenAlex

Web of science:	WOS:000425325300002
Scopus:	2-s2.0-85040664121
OpenAlex:	W2784058938

DB	Citing
OpenAlex	20
Scopus	20
Web of science	19