Mono- and binuclear complexes of copper(II) with dimethylaminomethyl derivatives of 2-naphthol and 6-quinolinol: synthesis and in vitro study of antitumor properties

Mono- and binuclear complexes of copper(II) with dimethylaminomethyl derivatives of 2-naphthol and 6-quinolinol: synthesis and in vitro study of antitumor properties Научная публикация

Журнал

Metallomics
ISSN: 1756-591X , E-ISSN: 1756-5901

Вых. Данные

Год: 2023, Том: 15, Номер: 6, Номер статьи : mfad037, Страниц : DOI: 10.1093/mtomcs/mfad037

Авторы

Akhmetova Vnira R. ¹ , Galimova El'mira M. ¹ , Mescheryakova Ekaterina S. ¹ , Dzhemileva Lilya U. ² , Dzhemilev Usein M. ² , D'yakonov Vladimir A. ²

Организации

1	Institute of Petrochemistry and Catalysis, Russian Academy of Sciences , 450075, Prospekt Oktyabrya 141, Ufa , Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 119991, Leninsky Prospekt 47, Moscow , Russia

1-(Dimethylamino)methyl-6-quinolinol scaffold, a structural moiety of the molecule of anticancer drug topotecan, was modified into copper-containing products to study cytotoxic properties. New mononuclear and binuclear Cu(II) complexes with 1-(N,N-dimethylamino)methyl-6-quinolinol were synthesized for the first time. The same way Cu(II) complexes with 1-(dimethylamino)methyl-2-naphtol ligand were synthesized. The structures of mono- and binuclear Cu(II) complexes with 1-aminomethyl-2-naphtol were confirmed by X-ray diffraction. The obtained compounds were examined for in vitro cytotoxic activity against Jurkat, K562, U937, MDA-MB-231, MCF7, T47D, and HEK293 cells. The induction of apoptosis and the effect of novel Cu complexes on the cell cycle were investigated. The cells showed a higher sensitivity to mononuclear Cu(II) complex with 1-(N,N-dimethylamino)methyl-6-quinolinolligand. All synthesized Cu(II) complexes had higher antitumor activity than the drugs topotecan, camptothecin, and platinum containing cisplatin.

Akhmetova V.R. , Galimova E.M. , Mescheryakova E.S. , Dzhemileva L.U. , Dzhemilev U.M. , D'yakonov V.A.
Mono- and binuclear complexes of copper(II) with dimethylaminomethyl derivatives of 2-naphthol and 6-quinolinol: synthesis and in vitro study of antitumor properties
Metallomics. 2023. V.15. N6. mfad037 . DOI: 10.1093/mtomcs/mfad037 WOS Scopus OpenAlex

Web of science:	WOS:001019051100001
Scopus:	2-s2.0-85164062991
OpenAlex:	W4380885455

БД	Цитирований
OpenAlex	4
Web of science	4
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