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Synthesis, Structure, and Biological Activity of 2,6-Disubstituted 2,3a,4a,6,7a,8a-Hexaazaperhydrocyclopenta[def]fluorene-4-thioxo­-8-ones Full article

Journal Synthesis
ISSN: 1437-210X , E-ISSN: 0039-7881
Output data Year: 2018, Volume: 50, Number: 10, Pages: 2099-2105 Pages count : 7 DOI: 10.1055/s-0036-1591952
Authors Barsegyan Yana A. 1,2 , Baranov Vladimir V. 2 , Kravchenko Angelina N. 2 , Strelenko Yuri A. 2 , Anikina Lada V. 3 , Karnoukhova Valentina A. 4 , Kolotyrkina Natalya G. 2
Affiliations
1 D. Mendeleev University of Chemical Technology of Russia
2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
3 Institute of Physiologically Active Substances, Russian Academy of Sciences
4 A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Abstract: A two-step one-pot condensation for the synthesis of previously inaccessible 2,6-disubstituted 2,3a,4a,6,7a,8a-hexaazaperhydrocyclopenta[def]fluorene-4-thioxo-8-ones from simple reagents [5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-one, paraformaldehyde and amines] was developed. The structure, antimicrobial, and anticancer activity of a number of synthesized compounds were studied.
Cite: Barsegyan Y.A. , Baranov V.V. , Kravchenko A.N. , Strelenko Y.A. , Anikina L.V. , Karnoukhova V.A. , Kolotyrkina N.G.
Synthesis, Structure, and Biological Activity of 2,6-Disubstituted 2,3a,4a,6,7a,8a-Hexaazaperhydrocyclopenta[def]fluorene-4-thioxo­-8-ones
Synthesis. 2018. V.50. N10. P.2099-2105. DOI: 10.1055/s-0036-1591952 WOS Scopus OpenAlex
Identifiers:
Web of science: WOS:000431026400018
Scopus: 2-s2.0-85046160126
OpenAlex: W2792111292
Citing:
DB Citing
OpenAlex 12
Scopus 13
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