Four-component stereoselective synthesis of tetracyano-substituted piperidines Научная публикация
Журнал |
Research on Chemical Intermediates
ISSN: 0922-6168 , E-ISSN: 1568-5675 |
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Вых. Данные | Год: 2018, Том: 44, Номер: 9, Страницы: 5623-5634 Страниц : 12 DOI: 10.1007/s11164-018-3444-7 | ||||
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Реферат:
A novel four-component stereoselective synthesis of polysubstituted piperidines is reported. The Knoevenagel–Michael–Mannich cascade of two equivalents of aromatic aldehydes, formaldehyde, two equivalents of malononitrile and ammonium acetate provides convenient access to the 2,6-diaryl-3,3,5,5-tetracyanopiperidines in good to excellent yields. Ammonium acetate plays a role both as a catalyst and as a nitrogen source. The formation of products is highly stereoselective. Structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, elemental analysis and mass spectral studies. 2,6-diphenylpiperidine-3,3,5,5-tetracarbonitrile was characterized by X-ray diffraction.
Библиографическая ссылка:
Vereshchagin A.N.
, Karpenko K.A.
, Elinson M.N.
, Goloveshkin A.S.
, Ushakov I.E.
, Egorov M.P.
Four-component stereoselective synthesis of tetracyano-substituted piperidines
Research on Chemical Intermediates. 2018. V.44. N9. P.5623-5634. DOI: 10.1007/s11164-018-3444-7 WOS Scopus OpenAlex
Four-component stereoselective synthesis of tetracyano-substituted piperidines
Research on Chemical Intermediates. 2018. V.44. N9. P.5623-5634. DOI: 10.1007/s11164-018-3444-7 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: | WOS:000441789200041 |
Scopus: | 2-s2.0-85046040774 |
OpenAlex: | W2803032811 |