Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors

Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors Full article

Journal

ACS Sustainable Chemistry & Engineering
ISSN: 2168-0485

Output data

Year: 2018, Volume: 6, Number: 2, Pages: 2535-2540 Pages count : 6 DOI: 10.1021/acssuschemeng.7b04029

Authors

Kuchurov Ilya V. ¹ , Arabadzhi Svetlana S. ² , Zharkov Mikhail N. ¹ , Fershtat Leonid L. ¹ , Zlotin Sergei G. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russian Federation
2	Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya square 9, 125047 Moscow, Russian Federation

A highly efficient, safe, and sustainable procedure was developed for the synthesis of various pharmacology-relevant and/or energy-rich nitroesters. It is based on nitration of corresponding alcohols with dinitrogen pentoxide in the liquid 1,1,1,2-tetrafluoroethane medium. The proposed approach is attractive for commercial applications because it offers significant advantages such as mild and clean reaction conditions, low operation pressure, available equipment, scalability, and facile fluid recycling. Structure–NO donor activity correlations were elucidated by an in vitro Griess assay for synthesized nitroesters and the obtained data may be useful for further in vivo experiments.

Kuchurov I.V. , Arabadzhi S.S. , Zharkov M.N. , Fershtat L.L. , Zlotin S.G.
Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors
ACS Sustainable Chemistry & Engineering. 2018. V.6. N2. P.2535-2540. DOI: 10.1021/acssuschemeng.7b04029 WOS Scopus OpenAlex

Web of science:	WOS:000424728300109
Scopus:	2-s2.0-85041485047
OpenAlex:	W2778223810

DB	Citing
OpenAlex	14
Scopus	13
Web of science	11