Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release

Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2018, Volume: 67, Number: 1, Pages: 95-101 Pages count : 7 DOI: 10.1007/s11172-018-2042-6

Authors

Konstantinova L.S. ¹ , Knyazeva E.A. ¹ , Gatilov Yu.V. ² , Zlotin S.G. ¹ , Rakitin O.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 prosp. Akad. Lavrent’eva, 630090, Novosibirsk, Russian Federation

A convenient one-pot synthesis of nitro derivatives of 2,1,3-benzothiadiazole 1-oxides by the reaction of o-nitroanilines with sulfur monochloride was developed. The structural features of 4-nitrobenzothiadiazole and its N-oxide were considered. High in vitro release of nitric oxide (69%) was found for a 6-nitro-2,1,3-benzothiadiazole sample by the Griess assay, which indicated good prospects for this class of compounds.

Konstantinova L.S. , Knyazeva E.A. , Gatilov Y.V. , Zlotin S.G. , Rakitin O.A.
Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release
Russian Chemical Bulletin. 2018. V.67. N1. P.95-101. DOI: 10.1007/s11172-018-2042-6 WOS Scopus OpenAlex

Web of science:	WOS:000430480200013
Scopus:	2-s2.0-85045841618
OpenAlex:	W2799463913

DB	Citing
OpenAlex	14
Scopus	15
Web of science	14