Stereoselective one-pot synthesis of polycyanosubstituted piperidines Научная публикация
Журнал |
Monatshefte Fur Chemie
ISSN: 1434-4475 , E-ISSN: 0026-9247 |
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Вых. Данные | Год: 2018, Том: 149, Номер: 11, Страницы: 1979-1989 Страниц : 11 DOI: 10.1007/s00706-018-2187-x | ||||
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Реферат:
An effective and facile multicomponent method for the synthesis of polysubstituted piperidines is described. The Michael–Mannich type cascade of benzylidenemalononitriles with aromatic aldehydes and ammonium acetate or aqueous ammonia provides convenient access to the stereoselective synthesis of 3,3,5,5-tetracyano-2,4,6-triarylpiperidines in good to excellent yields in one-pot manner. Ammonium acetate or aqueous ammonia plays a role both as a catalyst and as a nitrogen source. It is established that the reaction proceeds via sequence of equilibriums and a competitive mechanisms are implemented.
Библиографическая ссылка:
Vereshchagin A.N.
, Karpenko K.A.
, Elinson M.N.
, Gorbunov S.V.
, Gordeeva A.M.
, Proshin P.I.
, Goloveshkin A.S.
, Egorov M.P.
Stereoselective one-pot synthesis of polycyanosubstituted piperidines
Monatshefte Fur Chemie. 2018. V.149. N11. P.1979-1989. DOI: 10.1007/s00706-018-2187-x WOS Scopus OpenAlex
Stereoselective one-pot synthesis of polycyanosubstituted piperidines
Monatshefte Fur Chemie. 2018. V.149. N11. P.1979-1989. DOI: 10.1007/s00706-018-2187-x WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: | WOS:000446500100006 |
Scopus: | 2-s2.0-85053415288 |
OpenAlex: | W2890321523 |