5‐Indolylidene‐2‐iminothiazolidin‐4‐ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives

5‐Indolylidene‐2‐iminothiazolidin‐4‐ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives Full article

Journal

ChemistrySelect
ISSN: 2365-6549

Output data

Year: 2022, Volume: 7, Number: 2, Article number : e202104128, Pages count : DOI: 10.1002/slct.202104128

Authors

Izmest'ev Alexei N. ¹ , Streltsov Andrey A. ^2,1 , Karnoukhova Valentina A. ³ , Kolotyrkina Natalya G. ¹ , Strelenko Yurii A. ¹ , Kravchenko Angelina N. ¹ , Gazieva Galina A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences 47 Leninsky Prosp. 119991 Moscow Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia 9 Miusskaya Sq. 125047 Moscow Russian Federation
3	A. N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences 28 Vavilova Str. 119991 Moscow Russian Federation

A convenient method for the synthesis of novel dispirooxindoles containing 2-iminothiazolidin-4-one moiety has been proposed. The method relies on a 1,3-dipolar cycloaddition of azomethine ylides generated in situ from paraformaldehyde and N-alkyl amino acids including chiral ones to 5-indolylidene-2-iminothiazolidin-4-ones. The method is suitable for preparing enantiomerically pure derivatives.

Izmest'ev A.N. , Streltsov A.A. , Karnoukhova V.A. , Kolotyrkina N.G. , Strelenko Y.A. , Kravchenko A.N. , Gazieva G.A.
5‐Indolylidene‐2‐iminothiazolidin‐4‐ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives
ChemistrySelect. 2022. V.7. N2. e202104128 . DOI: 10.1002/slct.202104128 WOS Scopus OpenAlex

≡ Web of science:	WOS:000753970000017
≡ Scopus:	2-s2.0-85123690051
≡ OpenAlex:	W4205305305