Diastereoselective multicomponent synthesis of (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates

Diastereoselective multicomponent synthesis of (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2018, Volume: 67, Number: 11, Pages: 2049-2053 Pages count : 5 DOI: 10.1007/s11172-018-2327-9

Authors

Vereshchagin A.N. ¹ , Karpenko K.A. ¹ , Iliyasov T.M. ¹ , Elinson M.N. ¹ , Dorofeeva E.O. ¹ , Fakhrutdinov A.N. ¹ , Egorov M.P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Multicomponent reaction of benzylidenemalononitrile, 2-acetyl-3-arylacrylates, and aqueous ammonia in alcohols at room temperature proceeds stereoselectively to give (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates in 55–87% yields. In this reaction, ammonia acts as both the catalyst and the source of nitrogen for constructing tetrahydropyridine cycle.

Vereshchagin A.N. , Karpenko K.A. , Iliyasov T.M. , Elinson M.N. , Dorofeeva E.O. , Fakhrutdinov A.N. , Egorov M.P.
Diastereoselective multicomponent synthesis of (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates
Russian Chemical Bulletin. 2018. V.67. N11. P.2049-2053. DOI: 10.1007/s11172-018-2327-9 WOS Scopus OpenAlex

Web of science:	WOS:000454510700014
Scopus:	2-s2.0-85059352923
OpenAlex:	W2907808978

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OpenAlex	9
Scopus	12