Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products

Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products Обзор

Журнал

Beilstein Journal of Organic Chemistry
ISSN: 2195-951X , E-ISSN: 1860-5397

Вых. Данные

Год: 2014, Том: 10, Страницы: 34-114 Страниц : 81 DOI: 10.3762/bjoc.10.6

Авторы

Terent'ev Alexander O ¹ , Borisov Dmitry A ¹ , Vil Vera A ¹ , Dembitsky Valery M ^2,1

Организации

1	Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, 119991, Russia and
2	Institute for Drug Research, P.O. Box 12065, Hebrew University, Jerusalem 91120, Israel

The present review describes the current status of synthetic five and six-membered cyclic peroxides such as 1,2-dioxolanes, 1,2,4-trioxolanes (ozonides), 1,2-dioxanes, 1,2-dioxenes, 1,2,4-trioxanes, and 1,2,4,5-tetraoxanes. The literature from 2000 onwards is surveyed to provide an update on synthesis of cyclic peroxides. The indicated period of time is, on the whole, characterized by the development of new efficient and scale-up methods for the preparation of these cyclic compounds. It was shown that cyclic peroxides remain unchanged throughout the course of a wide range of fundamental organic reactions. Due to these properties, the molecular structures can be greatly modified to give peroxide ring-retaining products. The chemistry of cyclic peroxides has attracted considerable attention, because these compounds are used in medicine for the design of antimalarial, antihelminthic, and antitumor agents.

Terent'ev A.O. , Borisov D.A. , Vil V.A. , Dembitsky V.M.
Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products
Beilstein Journal of Organic Chemistry. 2014. V.10. P.34-114. DOI: 10.3762/bjoc.10.6 WOS Scopus OpenAlex

≡ Web of science:	WOS:000329820200001
≡ Scopus:	2-s2.0-84891923837
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