gem‐Difluoroolefination of Amides | Sciact - научная деятельность

gem‐Difluoroolefination of Amides Научная публикация

Журнал

Chemistry: A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Вых. Данные

Год: 2023, Том: 29, Номер: 70, Номер статьи : e202303144, Страниц : DOI: 10.1002/chem.202303144

Авторы

Alexey Trifonov ¹ , Alexander Dilman ¹

Организации

1	Zelinsky Institute of Organic Chemistry RAS: FGBUN Institut organiceskoj himii imeni N D Zelinskogo Rossijskoj akademii nauk, Laboratory of Functional organic compounds, Leninsky prosp. 47, 119991 Moscow, RUSSIAN FEDERATION

A metal-free one-pot process for the gem-difluoroolefination of amides is described. The reaction is based on interaction of generated in situ α-chloroiminium salts with difluorinated phosphorus ylide formed from difluorocarbene and triphenylphosphine. The olefination involves nucleophile-assisted dephosphorylation and proceeds within one hour at low temperature. The gem-difluoroenamines were used in further transformations leading to a variety of fluoroalkylated amines.

Alexey Trifonov , Alexander Dilman
gem‐Difluoroolefination of Amides
Chemistry: A European Journal. 2023. V.29. N70. e202303144 . DOI: 10.1002/chem.202303144 WOS Scopus OpenAlex

Web of science:	WOS:001086995600001
Scopus:	2-s2.0-85174461910
OpenAlex:	W4387503995

БД	Цитирований
OpenAlex	2
Scopus	2