Autocatalytic Green Synthesis of Imines in Traceless Medium

Autocatalytic Green Synthesis of Imines in Traceless Medium Full article

Journal

European Journal of Organic Chemistry
ISSN: 1434-193X , E-ISSN: 1099-0690

Output data

Year: 2023, Volume: 26, Number: 25, Article number : e202300366, Pages count : DOI: 10.1002/ejoc.202300366

Authors

Ivanov Roman ¹ , Ivanova Elizaveta ^1,2 , Merkulov Vladislav ^1,2 , Zharkov Mikhail ¹ , Kuchurov Ilya ¹ , Zlotin Sergei G. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation
2	Mendeleev University of Chemical Technology of Russia 9 Miusskaya sq. Moscow 125047 Russian Federation

For the first time, condensations of amines with carbonyl compounds have been performed in supercritical carbon dioxide (sc-CO2). The reactions with aldehydes or active ketones proceed at moderate temperatures (35–55 °C) without use of external catalysts. The process is autocatalytic: it is accelerated by the carbonic acid generated in situ by interaction between the released water and the CO2 medium. The imine products were obtained in high yields in a crystalline form and did not require further purification. The one-pot transfer hydrogenation and [4+2] cycloaddition reactions performed in the CO2 medium have uncovered attractive prospects for facile green synthesis of more complex and valuable compounds from the generated in situ imine products.

Ivanov R. , Ivanova E. , Merkulov V. , Zharkov M. , Kuchurov I. , Zlotin S.G.
Autocatalytic Green Synthesis of Imines in Traceless Medium
European Journal of Organic Chemistry. 2023. V.26. N25. e202300366 . DOI: 10.1002/ejoc.202300366 WOS Scopus OpenAlex

Web of science:	WOS:000999396900001
Scopus:	2-s2.0-85160813442
OpenAlex:	W4377989765

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