Solvent-free multicomponent assembling of aldehydes, N,N′-dialkyl barbiturates and malononitrile: fast and efficient approach to pyrano[2,3-d]pyrimidines

Solvent-free multicomponent assembling of aldehydes, N,N′-dialkyl barbiturates and malononitrile: fast and efficient approach to pyrano[2,3-d]pyrimidines Full article

Journal

Heterocyclic Communications
ISSN: 0793-0283 , E-ISSN: 2191-0197

Output data

Year: 2014, Volume: 20, Number: 5, Pages: 281-284 Pages count : 4 DOI: 10.1515/hc-2014-0114

Authors

Elinson Michail N. ¹ , Ryzhkov Fedor V. ¹ , Merkulova Valentina M. ¹ , Ilovaisky Alexey I. ¹ , Nikishin Gennady I. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991 Moscow, Russia

Potassium fluoride-catalyzed solvent-free multicomponent reaction of aldehydes, N,N′-dialkyl barbiturates and malononitrile results in the fast (15 min) and efficient (yields 89–95%) formation of substituted pyrano[2,3-d]pyrimidines. The improved synthetic methodology for this class of bioactive compounds is important from the viewpoint of diversity-oriented large-scale processes and represents an environmentally benign solvent-free synthetic concept for multicomponent reactions strategy.

Elinson M.N. , Ryzhkov F.V. , Merkulova V.M. , Ilovaisky A.I. , Nikishin G.I.
Solvent-free multicomponent assembling of aldehydes, N,N′-dialkyl barbiturates and malononitrile: fast and efficient approach to pyrano[2,3-d]pyrimidines
Heterocyclic Communications. 2014. V.20. N5. P.281-284. DOI: 10.1515/hc-2014-0114 WOS Scopus OpenAlex

Web of science:	WOS:000343262900005
Scopus:	2-s2.0-84908174585
OpenAlex:	W2329027663

DB	Citing
OpenAlex	20
Scopus	21
Web of science	23