Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4

Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4 Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2018, Volume: 51, Number: 10, Pages: 867-872 Pages count : 6 DOI: 10.1007/s11094-018-1706-8

Authors

Shirinyan V.Z. ¹ , Markosyan A.I. ² , Baryshnikova M.A. ³ , Yaminova L.V. ⁴ , L’vov A.G. ¹ , Gabrielyan S.A. ²

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia
3	N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
4	D. I. Mendeleev University of Chemical Technology of Russia, Moscow, Russia

A series of previously unreported di- and triaryl(hetaryl)cyclopentenone derivatives were prepared using a convenient synthetic method and screened preliminarily for antitumor activity in four human cell lines, i.e., T-cell leukemia (Jurkat), lung adenocarcinoma (A-549), colon cancer (HCT-116), and breast adenocarcinoma (MCF-7). The most cytotoxic of the tested compounds was 2-(3,4,5-trimethoxyphenyl)-3-(4-methoxyphenyl) cyclopent-2-en-1-one. However, it was inactive against lymphocytic leukemia P388 in mice despite its cytotoxicity in in vitro tests.

Shirinyan V.Z. , Markosyan A.I. , Baryshnikova M.A. , Yaminova L.V. , L’vov A.G. , Gabrielyan S.A.
Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4
Pharmaceutical Chemistry Journal. 2018. V.51. N10. P.867-872. DOI: 10.1007/s11094-018-1706-8 WOS Scopus OpenAlex

Web of science:	WOS:000423335800004
Scopus:	2-s2.0-85041128647
OpenAlex:	W2783024035

DB	Citing
OpenAlex	6
Scopus	6
Web of science	7