Synthesis and biological activities of organoaluminum steroids

Synthesis and biological activities of organoaluminum steroids Review

Journal

Vietnam Journal of Chemistry
ISSN: 0866-7144

Output data

Year: 2018, Volume: 56, Number: 6, Pages: 661-666 Pages count : 6 DOI: 10.1002/vjch.201800066

Authors

Dzhemilev Usein M. ¹ , D'Yakonov Vladimir A. ¹ , Tuktarova Regina A. ¹ , Gloriozova Tatyana A. ² , Dzhemileva Lilya U. ¹ , Terent'Ev Alexander O. ³ , Dembitsky Valery M. ^3,4

Affiliations

1	Institute of Petrochemistry and Catalysis of RAS, Ufa, Russia, 450075
2	Institute of Biomedical Chemistry, Moscow, Russia, 119121
3	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991
4	National Scientific Center of Marine Biology, Vladivostok, Russia, 690041

This review presents the synthesis of organoaluminum steroids (OAS) using catalytic cycloalumination of vinylcholestane and/or allylcholestane derivatives with Et3Al catalyzed by Cp2ZrCl2 which gives aluminacyclopentanes in a yield of about 90 %. Biological activity of synthesized organoaluminum steroids was determined with an aid of PASS program. Organoaluminum steroids showed antiprotozoal, antihypercholesterolemic, and antieczematic activity with a certainty from 78 to 92 %.

Dzhemilev U.M. , D'Yakonov V.A. , Tuktarova R.A. , Gloriozova T.A. , Dzhemileva L.U. , Terent'Ev A.O. , Dembitsky V.M.
Synthesis and biological activities of organoaluminum steroids
Vietnam Journal of Chemistry. 2018. V.56. N6. P.661-666. DOI: 10.1002/vjch.201800066 WOS Scopus OpenAlex

≡ Web of science:	WOS:001006447200002
≡ Scopus:	2-s2.0-85063602545
≡ OpenAlex:	W2927422774