Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane | Sciact

Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane Научная публикация

Журнал

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Вых. Данные

Год: 2016, Том: 18, Номер: 14, Страницы: 3458-3461 Страниц : 4 DOI: 10.1021/acs.orglett.6b01641

Авторы

Trifonov Alexey L. ^1,2 , Zemtsov Artem A. ² , Levin Vitalij V. ² , Struchkova Marina I. ² , Dilman Alexander D. ²

Организации

1	Higher Chemical College, Russian Academy of Sciences, 125047 Moscow, Miusskaya sq. 9, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.

A combination of (bromodifluoromethyl)trimethylsilane (Me3SiCF2Br), triphenylphosphine, and DMPU serves as a source of difluorinated phosphorus ylide Ph3P═CF2 under mild conditions. The system was used to effect nucleophilic difluoromethylation of ketones and nitro alkenes. The reaction efficiency is believed to be associated with Lewis acidic activation of the substrates by a silylium species formed upon generation of the phosphorus ylide.

Trifonov A.L. , Zemtsov A.A. , Levin V.V. , Struchkova M.I. , Dilman A.D.
Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane
Organic Letters. 2016. V.18. N14. P.3458-3461. DOI: 10.1021/acs.orglett.6b01641 WOS Scopus OpenAlex

Web of science:	WOS:000380182400039
Scopus:	2-s2.0-84978730683
OpenAlex:	W2462671140

БД	Цитирований
OpenAlex	55
Scopus	54