Fucoidans as a platform for new anticoagulant drugs discovery

Fucoidans as a platform for new anticoagulant drugs discovery Full article

Journal

Pure and Applied Chemistry
ISSN: 0033-4545 , E-ISSN: 1365-3075

Output data

Year: 2014, Volume: 86, Number: 9, Pages: 1365-1375 Pages count : 11 DOI: 10.1515/pac-2014-0404

Authors

Ustyuzhanina Nadezhda E. ¹ , Ushakova Natalia A. ² , Preobrazhenskaya Marina E. ² , Bilan Maria I. ¹ , Tsvetkova Eugenia A. ¹ , Krylov Vadim B. ¹ , Anisimova Natalia A. ³ , Kiselevskiy Mikhail V. ³ , Krukovskaya Nadezhda V. ¹ , Li Chunxia ⁴ , Yu Guangli ⁴ , Saran Saurabh ⁵ , Saxena Rajendra K. ⁵ , Usov Anatolii I. ¹ , Nifantiev Nikolay E. ¹

Affiliations

1	Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia
2	V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya str. 10, 119121 Moscow, Russia
3	N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe shosse, 24, 115478 Moscow, Russia
4	School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003 China,
5	Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi-110021, India

Anionic fucose-containing polysaccharides (fucoidans of brown seaweeds, sulfated fucans and fucosylated chondroitin sulfates of invertebrates) are attracting a rapidly growing research interest due to different types of their biological activity discovered in recent years. In particular, algal fucoidans are characterized by large structural variations depending on the species used for their isolation and by the lack of structural regularity due to random distribution of both carbohydrate and non-carbohydrate substituents along the polymer chains. These features make it difficult to find distinct correlations between structural elements and biological properties of polysaccharides. Nevertheless, there is expectation that systematic structural and biochemical studies of fucoidans will form a basis for the development of new drugs. Herewith we summarize our recent results on the influence of fucoidan structure on blood coagulation.

Ustyuzhanina N.E. , Ushakova N.A. , Preobrazhenskaya M.E. , Bilan M.I. , Tsvetkova E.A. , Krylov V.B. , Anisimova N.A. , Kiselevskiy M.V. , Krukovskaya N.V. , Li C. , Yu G. , Saran S. , Saxena R.K. , Usov A.I. , Nifantiev N.E.
Fucoidans as a platform for new anticoagulant drugs discovery
Pure and Applied Chemistry. 2014. V.86. N9. P.1365-1375. DOI: 10.1515/pac-2014-0404 WOS Scopus OpenAlex

≡ Web of science:	WOS:000345063100005
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