A fast and efficient ‘on-solvent’ cascade assembling of salicylaldehydes and dimethylbarbituric acid into 5-(1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-triones

A fast and efficient ‘on-solvent’ cascade assembling of salicylaldehydes and dimethylbarbituric acid into 5-(1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-triones Full article

Journal

Heterocyclic Communications
ISSN: 0793-0283 , E-ISSN: 2191-0197

Output data

Year: 2018, Volume: 24, Number: 2, Pages: 79-83 Pages count : 5 DOI: 10.1515/hc-2018-0015

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Korshunov Alexander D. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry , Leninsky Prospect 47 , 119991 Moscow , Russia

A fast (15 min) and efficient cascade reaction of salicylaldehydes and 1,3-dimethylbarbituric acid in the presence of p-TsOH as a catalyst furnishes substituted 5-(1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-triones 1a–h, containing both chromeno[2,3-d]pyrimidine and hexahydropyrimidine-2,4,6-trione pharmacologically active fragments, in 95–99% yields. This new procedure is characterized by the use of inexpensive reagents and a simple workup.

Elinson M.N. , Vereshchagin A.N. , Korshunov A.D. , Egorov M.P.
A fast and efficient ‘on-solvent’ cascade assembling of salicylaldehydes and dimethylbarbituric acid into 5-(1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-triones
Heterocyclic Communications. 2018. V.24. N2. P.79-83. DOI: 10.1515/hc-2018-0015 WOS Scopus OpenAlex

Web of science:	WOS:000429403900004
Scopus:	2-s2.0-85043278823
OpenAlex:	W2791990834

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