Electrocatalytic Fast and Efficient Aldol Addition of Pyrazoline-5-ones to Isatine

Electrocatalytic Fast and Efficient Aldol Addition of Pyrazoline-5-ones to Isatine Full article

Journal

Journal of The Electrochemical Society
ISSN: 0013-4651 , E-ISSN: 1945-7111

Output data

Year: 2014, Volume: 161, Number: 6, Pages: G48-G53 Pages count : DOI: 10.1149/2.104406jes

Authors

Elinson M.N. ¹ , Merkulova V.M. ¹ , Ilovaisky A.I. ¹ , Chizhov A.O. ¹ , Barba F. ² , Batanero B. ²

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Russia
2	Department of Organic Chemistry, University of Alcalá de Henares, Madrid 28871, Spain

The electrolysis of pyrazoline-5-ones and isatins in alcohols in an undivided cell results in the fast (16 min.) and efficient formation of the substituted 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indol-2-ones in 77-95% substance yields and 1540-1900% current efficiency. This novel electrocatalytic chain process opens a fast efficient and convenient way to functionalized 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indol-2-ones – the promising compounds for the different biomedical applications. Thus, the simple electrocatalytic system can produce in aprotic solvent in an undivided cell, under mild conditions the electrochemically induced aldol reaction of isatins and pyrazoline-5-ones.

Elinson M.N. , Merkulova V.M. , Ilovaisky A.I. , Chizhov A.O. , Barba F. , Batanero B.
Electrocatalytic Fast and Efficient Aldol Addition of Pyrazoline-5-ones to Isatine
Journal of The Electrochemical Society. 2014. V.161. N6. P.G48-G53. DOI: 10.1149/2.104406jes WOS Scopus OpenAlex

Web of science:	WOS:000339508600104
Scopus:	2-s2.0-84904812712
OpenAlex:	W2001326484

DB	Citing
OpenAlex	12
Scopus	11
Web of science	12