New insight into the antiaggregant activity of furoxans

New insight into the antiaggregant activity of furoxans Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2016, Volume: 26, Number: 6, Pages: 513-515 Pages count : 3 DOI: 10.1016/j.mencom.2016.11.018

Authors

Ustyuzhanina Nadezhda E. ¹ , Fershtat Leonid L. ¹ , Gening Marina L. ¹ , Nifantiev Nikolay E. ¹ , Makhova Nina N. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991,Moscow, Russian Federation

The measurement of the antiaggregant properties of 3-cyano-4-phenylfuroxan and 3-nitro-4-phenylfuroxan has demonstrated that these compounds effectively inhibit platelet agglutination induced by adenosine diphosphate and adrenaline but not ristocetin. When collagen was used as an inducer, only a slight delay of aggregate formation was observed. Therefore, these furoxan derivatives could be considered as a basis for the development of next generation agents with improved antiaggregant activity.

Ustyuzhanina N.E. , Fershtat L.L. , Gening M.L. , Nifantiev N.E. , Makhova N.N.
New insight into the antiaggregant activity of furoxans
Mendeleev Communications. 2016. V.26. N6. P.513-515. DOI: 10.1016/j.mencom.2016.11.018 WOS Scopus OpenAlex

≡ Web of science:	WOS:000390515200018
≡ Scopus:	2-s2.0-84997207236
≡ OpenAlex:	W2552907581