Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)–H arylation of furan core under Pd/NHC-catalysis

Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)–H arylation of furan core under Pd/NHC-catalysis Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2024, Volume: 34, Number: 2, Pages: 198-200 Pages count : 3 DOI: 10.1016/j.mencom.2024.02.012

Authors

Shepelenko Konstantin E. ¹ , Gnatiuk Irina G. ¹ , Minyaev Mikhail E. ² , Chernyshev Victor M. ¹

Affiliations

1	Platov South-Russian State Polytechnic University, 346428 Novocherkassk, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

An efficient procedure for the preparation of furo[2,3-c]-quinolin-4(5H)-ones from 2-furoic acid N-(o-bromoaryl)- amides via selective intramolecular C(3)–H arylation of the furan nucleus involves the catalysis by a Pd/NHC system generated in situ from Pd(OAc)2 and readily available IPrSPh HCl proligand. A series of novel furo[2,3-c]quinolin-4(5H)-ones were prepared in 65–80% isolated yields.

Shepelenko K.E. , Gnatiuk I.G. , Minyaev M.E. , Chernyshev V.M.
Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)–H arylation of furan core under Pd/NHC-catalysis
Mendeleev Communications. 2024. V.34. N2. P.198-200. DOI: 10.1016/j.mencom.2024.02.012 WOS Scopus OpenAlex

≡ Web of science:	WOS:001221400700001
≡ Scopus:	2-s2.0-85189359172
≡ OpenAlex:	W4393857015