Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H‐Pyrano‐[4,3‐b]pyran‐5‐one and 4,6‐Dihydro‐5H‐pyrano‐[3,2‐c]pyridine‐5‐one Scaffolds

Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H‐Pyrano‐[4,3‐b]pyran‐5‐one and 4,6‐Dihydro‐5H‐pyrano‐[3,2‐c]pyridine‐5‐one Scaffolds Full article

Journal

Helvetica Chimica Acta
ISSN: 1522-2675 , E-ISSN: 0018-019X

Output data

Year: 2016, Volume: 99, Number: 9, Pages: 724-731 Pages count : 8 DOI: 10.1002/hlca.201600150

Authors

Elinson Michail N. ¹ , Ryzhkov Fedor V. ¹ , Nasybullin Ruslan F. ¹ , Vereshchagin Anatoly N. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Leninsky Prospect 47 119991 Moscow Russia

The general ‘on-solvent’ PASE approach was found to be medicinally relevant for 4H,5H-pyrano[4,3-b]pyran-5-one and 4,6-dihydro-5H-pyrano[3,2-c]pyridine-5-one scaffolds. Ammonium acetate-catalyzed multicomponent reaction of aldehydes and two different C–H acids in the presence of small amounts of EtOH results in fast (3 – 15 min) and efficient formation of scaffolds, promising for many diverse oriented medical applications.

Elinson M.N. , Ryzhkov F.V. , Nasybullin R.F. , Vereshchagin A.N. , Egorov M.P.
Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H‐Pyrano‐[4,3‐b]pyran‐5‐one and 4,6‐Dihydro‐5H‐pyrano‐[3,2‐c]pyridine‐5‐one Scaffolds
Helvetica Chimica Acta. 2016. V.99. N9. P.724-731. DOI: 10.1002/hlca.201600150 Scopus OpenAlex

Scopus:	2-s2.0-84987704776
OpenAlex:	W2519650033

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