Synthesis of new pyrimido[4,5-d]pyrimidine derivatives from 5-acetyl-6-methyl-4-methylsulfanylpyrimidine-2(1H)-thiones and guanidine

Synthesis of new pyrimido[4,5-d]pyrimidine derivatives from 5-acetyl-6-methyl-4-methylsulfanylpyrimidine-2(1H)-thiones and guanidine Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 2014, Том: 63, Номер: 2, Страницы: 469-474 Страниц : 6 DOI: 10.1007/s11172-014-0454-5

Авторы

Komkov A.V. ¹ , Baranin S.V. ¹ , Dorokhov V.A. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Reactions of 5-acetyl-1-aryl(alkyl)-6-methyl-4-methylsulfanylpyrimidine-2(1H)-thiones (prepared from diacetylketene N,S-acetal) with guanidine afforded 3-alkyl- and 3-aryl-7-amino-5-methyl-4-methylidene-3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-thiones. By-products of these reactions (5-acetyl-1-alkyl(aryl)-6-methyl-2-thiouracils) can also be obtained from the starting pyrimidinethiones and EtONa in EtOH. Pyrimidopyrimidinethiones can react with MeOH at the methylidene group in the presence of MeONa.

Komkov A.V. , Baranin S.V. , Dorokhov V.A.
Synthesis of new pyrimido[4,5-d]pyrimidine derivatives from 5-acetyl-6-methyl-4-methylsulfanylpyrimidine-2(1H)-thiones and guanidine
Russian Chemical Bulletin. 2014. V.63. N2. P.469-474. DOI: 10.1007/s11172-014-0454-5 WOS Scopus OpenAlex

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