Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments

Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2015, Volume: 50, Number: 12, Pages: 1719-1726 Pages count : 8 DOI: 10.1007/s10593-015-1643-3

Authors

Butov G.M. ¹ , Burmistrov V.V. ¹ , Dalinger I.L. ² , Vatsadze I.A. ² , Shkineva T.K. ² , Danilov D.V. ¹

Affiliations

1	Volzhsky Polytechnical Institute, Branch of Volgograd State Technical University, 42а Engelsa St., Volzhsky, 404121, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow, 119991, Russia

A series of 1,3-disubstituted and 1,3,3-trisubstituted isoxazolyl- and adamantyl-functionalized ureas was synthesized. The resulting compounds are potent inhibitors of soluble epoxide hydrolase. The compounds were obtained in high yields under mild conditions. Water solubility of the synthesized ureas was found to exceed significantly that of known analogs.

Butov G.M. , Burmistrov V.V. , Dalinger I.L. , Vatsadze I.A. , Shkineva T.K. , Danilov D.V.
Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments
Chemistry of Heterocyclic Compounds. 2015. V.50. N12. P.1719-1726. DOI: 10.1007/s10593-015-1643-3 WOS Scopus OpenAlex

≡ Web of science:	WOS:000349913000010
≡ Scopus:	2-s2.0-84953352750
≡ OpenAlex:	W2043468382