Potassium fluoride catalysed multicomponent approach to medicinally privileged 5-[3-hydroxy-6-(hydroxymethyl)-4H-pyran-2-yl] substituted chromeno[2,3-b]pyridine scaffold Научная публикация
| Журнал |
Arkivoc
ISSN: 1551-7012 , E-ISSN: 1551-7004 |
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| Вых. Данные | Год: 2019, Том: 2019, Номер: 2, Страницы: 38-49 Страниц : 12 DOI: 10.24820/ark.5550190.p011.002 | ||
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Реферат:
The new efficient and facile multicomponent reaction was found: transformation of salicylaldehydes, kojic acid, and malononitrile dimer in the presence of potassium fluoride as catalyst in small amount of i-propanol results in formation of substituted 2,4-diamino-5-(3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl)-5Hchromeno[2,3-b]pyridine-3-carbonitriles in 56-93% yields. This complex “domino” transformation includes Knoevenagel condensation of salicylaldehyde with malononitrile dimer, Michael addition of kojic acid, double
Pinner type reaction cyclization, and isomerization with following protonation. The novel ‘one-pot’ process opens an efficient and convenient way to functionalized 5H-chromeno[2,3-b]pyridine systems, which are promising compounds for different biomedical applications.
Библиографическая ссылка:
Elinson M.N.
, Vereshchagin A.N.
, Anisina Y.E.
, Krymov S.K.
, Fakhrutdinov A.N.
, Egorov M.P.
Potassium fluoride catalysed multicomponent approach to medicinally privileged 5-[3-hydroxy-6-(hydroxymethyl)-4H-pyran-2-yl] substituted chromeno[2,3-b]pyridine scaffold
Arkivoc. 2019. V.2019. N2. P.38-49. DOI: 10.24820/ark.5550190.p011.002 WOS Scopus OpenAlex
Potassium fluoride catalysed multicomponent approach to medicinally privileged 5-[3-hydroxy-6-(hydroxymethyl)-4H-pyran-2-yl] substituted chromeno[2,3-b]pyridine scaffold
Arkivoc. 2019. V.2019. N2. P.38-49. DOI: 10.24820/ark.5550190.p011.002 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000483506000001 |
| Scopus: | 2-s2.0-85079035980 |
| OpenAlex: | W2976106692 |