Functionalization of NH-unsubstituted androstano[17,16-d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16-d]pyrazoles

Functionalization of NH-unsubstituted androstano[17,16-d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16-d]pyrazoles Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2016, Volume: 65, Number: 3, Pages: 819-821 Pages count : 3 DOI: 10.1007/s11172-016-1381-4

Authors

Chertkova V.V. ¹ , Chernoburova E.I. ¹ , Dzhafarov M.Kh. ² , Tyurin A.Yu. ¹ , Volkova Yu.A. ¹ , Vasilevich F.I. ² , Zavarzin I.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 23 ul. Akad. Skryabina, 119991, Moscow, Russian Federation

An approach to the synthesis of earlier unknown androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring has been suggested. The method is based on the reaction of NH-unsubstituted androstano[17,16-d]pyrazole with chloroacetyl chloride with subsequent involvement of the obtained N-chloroacetylpyrazole into the reaction with elementary sulfur in the presence of aromatic amines. The synthesized androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring exhibit high antiparasitic activity.

Chertkova V.V. , Chernoburova E.I. , Dzhafarov M.K. , Tyurin A.Y. , Volkova Y.A. , Vasilevich F.I. , Zavarzin I.V.
Functionalization of NH-unsubstituted androstano[17,16-d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16-d]pyrazoles
Russian Chemical Bulletin. 2016. V.65. N3. P.819-821. DOI: 10.1007/s11172-016-1381-4 WOS Scopus OpenAlex

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