Synthesis of 1-Adamantyl-3,4,5-R1,R2,R3-Pyrazoles

Synthesis of 1-Adamantyl-3,4,5-R1,R2,R3-Pyrazoles Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2014, Volume: 50, Number: 5, Pages: 752-756 Pages count : 5 DOI: 10.1007/s10593-014-1530-3

Authors

Butov G.M. ¹ , Lysykh B.A. ¹ , Dalinger I.L. ² , Vatsadze I.A. ² , Shkineva T.K. ² , Klimochkin Yu.N. ³ , Osyanin V.A. ³

Affiliations

1	Volzhsky Polytechnic Institute, Branch of the Volgograd State Technical University, 42a Engels St., Volzhsky, 404121, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Ave., Moscow, 119991, Russia
3	Samara State Technical University, 244 Molodogvardeiskaya St., Samara, 443100, Russia

A method has been developed for the synthesis of 1-adamantyl-3,4,5-R1,R2,R3-pyrazoles by the reaction of 1,3-dehydroadamantane with N-unsubstituted 3,4,5-R1,R2,R3-1H-pyrazoles in an inert solvent. The effect of the NH acidity (pKa) of the starting 3,4,5-R1,R2,R3-1H-pyrazole on the course of the reaction and the product yields was studied.

Butov G.M. , Lysykh B.A. , Dalinger I.L. , Vatsadze I.A. , Shkineva T.K. , Klimochkin Y.N. , Osyanin V.A.
Synthesis of 1-Adamantyl-3,4,5-R1,R2,R3-Pyrazoles
Chemistry of Heterocyclic Compounds. 2014. V.50. N5. P.752-756. DOI: 10.1007/s10593-014-1530-3 WOS Scopus OpenAlex

≡ Web of science:	WOS:000339963000018
≡ Scopus:	2-s2.0-84905098169
≡ OpenAlex:	W2041261252