Detonation nanodiamond complexes with cancer stem cells inhibitors or paracrine products of mesenchymal stem cells as new potential medications

Detonation nanodiamond complexes with cancer stem cells inhibitors or paracrine products of mesenchymal stem cells as new potential medications Full article

Journal

Crystallography Reports
ISSN: 1063-7745 , E-ISSN: 1562-689X

Output data

Year: 2015, Volume: 60, Number: 5, Pages: 763-767 Pages count : 5 DOI: 10.1134/s1063774515050041

Authors

Konoplyannikov A.G. ¹ , Alekseenskiy A.E. ² , Zlotin S.G. ³ , Smirnov B.B. ³ , Kalsina S.Sh. ¹ , Lepehina L.A. ¹ , Semenkova I.V. ¹ , Agaeva E.V. ¹ , Baboyan S.B. ¹ , Rjumshina E.A. ¹ , Nosachenko V.V. ¹ , Konoplyannikov M.A. ⁴

Affiliations

1	Medical Radiological Research Centre—Branch of the National Medical Radiological Research Centre, Ministry of Health of the Russian Federation, Obninsk, Russia
2	Ioffe Physical and Technical Institute, Russian Academy of Sciences, St. Petersburg, Russia
3	Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
4	Federal Research Clinical Centre of Specialized Medical Aid and Medical Methods of the Federal Medical and Biological Agency, Ministry of Health of the Russian Federation, Moscow, Russia

Combined use of complexes of the most active chemotherapeutic drugs and detonation nanodiamonds (DND) is a new trend in cancer therapy, which is probably related to selective chemotherapeutic drug delivery by DND to the zone of so-called cancer stem cells (CSC). Stable DND complexes of 4–5 nm size with salinomycin—a strong CSC inhibitor—have been obtained (as a suspension). It has been demonstrated that a complex administration considerably increases the drug antitumor effect on the transplantable tumor of LLC mice. A similar effect has been observed in CSC models in vivo, obtained by exposure of stem cells of normal mice tissues to a carcinogen 1,2-dimethylhydrazine. It has also been found out, that administration of DND complexes with the conditioned medium from mesenchymal stem cells (MSC) cultures to mice results in a considerable stimulation of stem cell pools in normal mice tissues, which can be used in regenerative medicine.

Konoplyannikov A.G. , Alekseenskiy A.E. , Zlotin S.G. , Smirnov B.B. , Kalsina S.S. , Lepehina L.A. , Semenkova I.V. , Agaeva E.V. , Baboyan S.B. , Rjumshina E.A. , Nosachenko V.V. , Konoplyannikov M.A.
Detonation nanodiamond complexes with cancer stem cells inhibitors or paracrine products of mesenchymal stem cells as new potential medications
Crystallography Reports. 2015. V.60. N5. P.763-767. DOI: 10.1134/s1063774515050041 WOS Scopus OpenAlex

Web of science:	WOS:000361439500025
Scopus:	2-s2.0-84941947384
OpenAlex:	W2273732115

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