Investigation of the effect of steroidal imidazoheterocycles hormone derivatives on JEG-3 trophoblast cells of choriocarcinoma

Investigation of the effect of steroidal imidazoheterocycles hormone derivatives on JEG-3 trophoblast cells of choriocarcinoma Full article

Journal

Kragujevac Journal of Science
ISSN: 1450-9636

Output data

Year: 2021, Number: 43, Pages: 99-107 Pages count : 9 DOI: 10.5937/kgjsci2143099t

Authors

Todosijević Jovana ¹ , Scherbakov Alexander ² , Volkova Yulia ³ , Jurišić Vladimir ⁴

Affiliations

1	University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac, Serbia
2	N.N. Blokhin National Medical Research Center of Oncology, Department of experimental Tumor Biology, 24 Kashirskoe shosse, 115522, Moscow, Russia
3	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russia
4	Unversity of Kragujevac, Faculty of Medical Sciences, Svetozara Markovića 69, 34000 Kragujevac, Serbia

This study aimed to examine the biological activities of unique steroid hormone derivatives-steroidal imidazoheterocycles. The activity synthesized steroidal compounds were tested for the viability of JEG-3 trophoblast cells of choriocarcinoma. The results of the MTT cytotoxicity test showed that most of the examined steroidal imidazoheterocycles act proliferatively on the JEG-3 cell line, except (E, F, and J). Antiproliferative activity of these derivates is probably influenced by different substituents at position 17-C atom in the chemical structure of the hormone and by different substituents on the oxygen atom of acetamide group in the hormone molecule. In order to better confirm the antiproliferative activity of these derivatives, it is necessary to performed complex research on a large panel of cancer cell lines and by different assay.

Todosijević J. , Scherbakov A. , Volkova Y. , Jurišić V.
Investigation of the effect of steroidal imidazoheterocycles hormone derivatives on JEG-3 trophoblast cells of choriocarcinoma
Kragujevac Journal of Science. 2021. N43. P.99-107. DOI: 10.5937/kgjsci2143099t OpenAlex

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