Photoredox-Catalyzed Four-Component Reaction for the Synthesis of Complex Secondary Amines

Photoredox-Catalyzed Four-Component Reaction for the Synthesis of Complex Secondary Amines Full article

Journal

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Output data

Year: 2020, Volume: 22, Number: 9, Pages: 3318-3322 Pages count : 5 DOI: 10.1021/acs.orglett.0c00614

Authors

Kammer Lisa Marie ¹ , Krumb Matthias ¹ , Spitzbarth Benjamin ¹ , Lipp Benjamin ¹ , Kühlborn Jonas ¹ , Busold Jonas ¹ , Olga M Mulina ² , Alexander O Terentev ² , Opatz Till ¹

Affiliations

1	Department of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russia

The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing substituted γ-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Besides one molecule of water and the sodium counterion of the sulfinate, all atoms of the starting materials are transferred to the final product, rendering this process highly atom-efficient. The operationally simple protocol allows for the simultaneous formation of three new single bonds (C–S, C–N, and C–C) and therefore grants rapid access to structurally diverse products.

Kammer L.M. , Krumb M. , Spitzbarth B. , Lipp B. , Kühlborn J. , Busold J. , Olga M Mulina , Alexander O Terentev , Opatz T.
Photoredox-Catalyzed Four-Component Reaction for the Synthesis of Complex Secondary Amines
Organic Letters. 2020. V.22. N9. P.3318-3322. DOI: 10.1021/acs.orglett.0c00614 WOS Scopus OpenAlex

Web of science:	WOS:000530076400004
Scopus:	2-s2.0-85081962909
OpenAlex:	W3010911651

DB	Citing
OpenAlex	38
Scopus	38
Web of science	35