Stereoselective domino assembling of five molecules: one-pot approach to (2R',3S,4'R)-2',4'-diaryl-1',4'-dihydro-2'H-spiro[indoline-3,3'-pyridines]

Stereoselective domino assembling of five molecules: one-pot approach to (2R',3S,4'R)-2',4'-diaryl-1',4'-dihydro-2'H-spiro[indoline-3,3'-pyridines] Full article

Journal

Comptes Rendus Chimie
ISSN: 1878-1543 , E-ISSN: 1631-0748

Output data

Year: 2020, Volume: 23, Number: 2, Pages: 159-168 Pages count : 10 DOI: 10.5802/crchim.13

Authors

Ryzhkov Fedor V. ¹ , Elinson Michail N. ¹ , Ryzhkova Yuliya E. ¹ , Vereshchagin Anatoly N. ¹ , Goloveshkin Alexander S. ² , Egorov Mikhail P. ¹

Affiliations

1	Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russian Federation
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova 28, 119334, Moscow, Russian Federation.

A new stereoselective multicomponent reaction has been found: domino assembling of two equivalents of benzaldehyde, malononitrile, oxindole and excess of ammonium acetate in acetonitrile resulted in the formation of previously unknown --amino-2-oxo--diaryl--dihydro--spiro[indoline--pyridine]--carbonitriles. Optimized reaction conditions and a mechanistic rationale for this multicomponent transformation are presented. This complex one-pot process occurs under mild conditions. The final compounds need no labor-intensive purification.

Ryzhkov F.V. , Elinson M.N. , Ryzhkova Y.E. , Vereshchagin A.N. , Goloveshkin A.S. , Egorov M.P.
Stereoselective domino assembling of five molecules: one-pot approach to (2R',3S,4'R)-2',4'-diaryl-1',4'-dihydro-2'H-spiro[indoline-3,3'-pyridines]
Comptes Rendus Chimie. 2020. V.23. N2. P.159-168. DOI: 10.5802/crchim.13 WOS Scopus OpenAlex

Web of science:	WOS:000573968300005
Scopus:	2-s2.0-85108302090
OpenAlex:	W3036246050

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