Реферат: The review summarizes the publications, available at the time it was written, addressing the chemical and biological processes that occur in the human body upon exposure to coronaviruses, in particular SARS-CoV-2. The mechanisms of viral particle entry into the cell, viral replication and impact on the immune system and on oxygen transport system are considered. The causes behind complications of the viral infection, such as vasculitis, thrombosis, cytokine storm and lung fibrosis, are discussed. The latest research in the field of small molecule medications to counteract the virus is surveyed. Molecular targets and possible vectors to exploit them are considered. The review is primarily written for specialists who want to understand the chains of activation, replication, action and inhibition of SARS-CoV-2. Due to the short period of such studies, the data on complexes of small molecule compounds with possible protein targets are not numerous, but they will be useful in the search and synthesis of new potentially effective drugs. The bibliography includes 144 references.

Библиографическая ссылка: Novikov F.N. , Stroylov V.S. , Svitanko I.V. , Nebolsin V.E.
Molecular basis of COVID-19 pathogenesis
Russian Chemical Reviews. 2020. V.89. N8. P.858-878. DOI: 10.1070/RCR4961 WOS Scopus OpenAlex

Идентификаторы БД:

Web of science:	WOS:000547005000004
Scopus:	2-s2.0-85088016248
OpenAlex:	W3026282994

Цитирование в БД:

БД	Цитирований
OpenAlex	17
Web of science	16
Scopus	16

Альметрики: