Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro

Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2015, Volume: 25, Number: 5, Pages: 364-366 Pages count : 3 DOI: 10.1016/j.mencom.2015.09.016

Authors

Rakitina Tatiana V. ^1,2 , Zeifman Alexey A. ³ , Novikov Fedor N. ³ , Stroganov Oleg V. ³ , Stroylov Victor S. ³ , Svitanko Igor V. ^3,4 , Frank-Kamenetskii Anastasia ¹ , Chilov Ghermes G. ³

Affiliations

1	National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation
2	M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation.
3	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
4	Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation

Six novel potential PARP1 inhibitors were identified by means of substructure search and molecular docking into PAPR1 active site; one compound (STK970217) potentiated the cytotoxicity of doxorubicin in hepatocellular carcinoma HepG2 cells being non-cytotoxic as a single agent, while three other identified compounds inhibited the growth of HepG2 cells both individually and in combination with doxorubicin.

Rakitina T.V. , Zeifman A.A. , Novikov F.N. , Stroganov O.V. , Stroylov V.S. , Svitanko I.V. , Frank-Kamenetskii A. , Chilov G.G.
Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro
Mendeleev Communications. 2015. V.25. N5. P.364-366. DOI: 10.1016/j.mencom.2015.09.016 WOS Scopus OpenAlex

Web of science:	WOS:000363350500016
Scopus:	2-s2.0-84943261323
OpenAlex:	W1878296260

DB	Citing
OpenAlex	4
Scopus	4
Web of science	4