“Metal-free” synthesis and antifungal activity of 3-thiocyanatopyrazolo[1,5-a]pyrimidines

“Metal-free” synthesis and antifungal activity of 3-thiocyanatopyrazolo[1,5-a]pyrimidines Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2021, Volume: 70, Number: 3, Pages: 600-604 Pages count : 5 DOI: 10.1007/s11172-021-3131-5

Authors

Kokorekin V.A. ^1,2 , Khodonov V.M. ^1,2 , Neverov S.V. ¹ , Grammatikova N.É. ³ , Petrosyan V.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
2	I. M. Sechenov First Moscow State Medical University, Ministry of Healthcare of the Russian Federation (Sechenov University), Moscow, Russian Federation
3	G. F. Gause Research Institute of New Antibiotics, Moscow, Russian Federation

A convenient stepwise synthesis of substituted 3-thiocyanatopyrazolo[1,5-a]pyrimidines under mild conditions using available reagents and solvents was proposed. A number of these compounds were found to possess pronounced and selective antifungal activity, which is comparable or superior to the activity of the antifungal drugs amphotericin B and fluconazole.

Kokorekin V.A. , Khodonov V.M. , Neverov S.V. , Grammatikova N.É. , Petrosyan V.A.
“Metal-free” synthesis and antifungal activity of 3-thiocyanatopyrazolo[1,5-a]pyrimidines
Russian Chemical Bulletin. 2021. V.70. N3. P.600-604. DOI: 10.1007/s11172-021-3131-5 WOS Scopus OpenAlex

≡ Web of science:	WOS:000633737400028
≡ Scopus:	2-s2.0-85103585456
≡ OpenAlex:	W3144998125